Vascular Endothelial Growth Factor, Epidermal Growth Factor, and Epithelialization Analysis on Full-Thickness Wound Applied with Topical Erythropoietin

BACKGROUND: Skin wounds are a major challenge, such as full-thickness that need long time to heal. However, the addition of erythropoietin can accelerate wound healing process. AIM: This study was aimed determine effect topical administration on vascular endothelial growth factor (VEGF), epidermal (EGF), and epithelialization in METHODS: randomized controlled trial. Full-thickness were created back each white rat. No treatment administered control group (n=16), applied (n=16). The rats euthanized day 3 6 post-surgery, respectively. expression levels VEGF, EGF, microscopic rate examined. RESULTS: level EGF increased significantly by 2.84 times compared 4.89 (p < 0.001). VEGF 2.18 2.65 Meanwhile, 1.3 up 7.62 CONLUSION: Topical could increase both early inflammatory proliferative phases.